ReLaunch Your Youth with the Future of Skin Rejuvenation

Hilary DeCesare: 00:00:00

Welcome, everybody. And we are once again, at the point where I am saying this is The ReLaunch Podcast. And today, we've all heard about medical procedures we've heard about trying to capture the fountain of youth. But how do you actually do that and what's really involved as technology as new advancements are coming out. Today. I have the most incredible gal I've had the privilege of literally getting to know her. Her stories are amazing. She has risen to the top, she is dedicated, she is moving forward with trying to bring these incredible products to a new group of individuals that are so desperately needing the non invasive. This is what we're focused on. today. We're focused on not having to go under the knife as we age. Dr. Gail Humble she brings a commitment to perform the art and science of aesthetic medicine. And she is like elevating out non surgical procedures, these ones that allow him to enhance to mold to shape and improve the face and the body. And Dr. Humble is originally from my home plays Northern California, where she received her undergraduate degree in genetics from UC Davis. She then received her medical degree from the University of Texas and following a residency at USC. She received her boards in anesthesia as well. She has done a fellowship at for anti aging she's talked about in front of anti aging Congress, she is boarded by the American Board of laser medicine and surgery. I mean, the list goes on and on. She is an author of multiple medical and non medical articles, as well as several medical journals. She is a frequent lecturer on anti aging medicine with World Congress, she talks about skin disease, all of this so important. When she starts to talk about what she has created. She is one of the first non surgical cosmetic practices out there. And she has served as the associate professor at USC, again talking but here's the most important. Gail believes Dr. Gail believes that beauty is a reflection of the person inside. When we feel young, when we feel beautiful when we feel handsome. Our image in the mirror should absolutely reflect that. And she presently right now she has she is in practice, northern Southern California. But today, she has with us to bring us the tips, the tricks the what should we be doing? How does this all impact us? Dr. Gail, welcome to the relaunch podcast.

Hilary DeCesare: 00:03:23

Dr. Gail Humble: Well, thank you for having me, Hillary, it's an honor to be here. Well,

Hilary DeCesare: 00:03:27

this has been really an interesting, kind of like, I've been reading so much about what you've done, I've actually had the privilege of using your products now for over a month. So we're gonna get into that we're going to talk more about that how this all came to be. But I really I want to start with your relaunch story around how you got into this space and where this incredible passion actually started from?

Hilary DeCesare: 00:04:00

Dr. Gail Humble: Absolutely. Well, I haven't practiced and aesthetic in regenerative medicine and background in genetics. And I think one of my biggest frustrations is that although both fields are progressing nicely, we still treat diseases once they happen, rather than prevent them. So in the example of aesthetics, we wait until our skin is photo damaged or we have wrinkles and then we use neurotoxins, fillers and lasers to treat it. My thought was what if we can actually change the way our skin ages? What if we can change the aging process?

Hilary DeCesare: 00:04:44

I'm sure everyone's like, okay, yes, I need your more. I'm not going anywhere right now. I'm like glued to the screen right now or to the airwaves. Yes. This is so incredible, because we do we wait until we see a problem. Oh no. Oh, the aging effect has happened. That is so true. I know I I've just recently done that where I'm like, Oh my God, is it the dry weather in Boulder? Or am I just getting older?

Hilary DeCesare: 00:05:13

Dr. Gail Humble: You look amazing.

Hilary DeCesare: 00:05:15

Thanks. Thanks for the products. We're going to talk about it. Okay. So interesting. So you really started and you were you were you were a in it. You were one of those thought leaders, you were the the one that's going out and, you know, kind of blazing the trail around this because this wasn't what people were doing. Absolutely.

Hilary DeCesare: 00:05:36

Dr. Gail Humble: It was interesting. The first article, well, let's go back. The entire summary of changing the aging process is what brought me to to learn and study and do research for 20 years on the Klotho gene. Now, this is the only age suppressing gene known to be in mammals. It was discovered in 1997 by Corolla Japanese scientists, that's when I first read about it. In this first clinical publication, he noticed in a wild strain of Mouse one of the mice lived 31% longer, and every system stayed younger. There was a fellow mouse same wild mouse strain, he had a downregulation of the Clutha gene called though is spelled k l o t h o. And when the mouse had a downregulation at the club, that gene that mouse died at 5% of his lifespan with early dementia, pulmonary emphysema, renal disease, cardiovascular disease, thinning and a trophic. Skin and lousy hair.

Hilary DeCesare: 00:06:48

Everyone out there listening. So we have you found in these mice, there was this close, though gene. And one had, as you said, a down regulation, which means one had more of the Klotho gene order under producing, okay, under the under producing one died earlier.

Hilary DeCesare: 00:07:10

Dr. Gail Humble: Yes, with advanced aging,

Hilary DeCesare: 00:07:13

with advanced aging. Okay, so now I'm following you. And so what did you surmise? What did you then say, Huh? Like you well, all

Hilary DeCesare: 00:07:25

Dr. Gail Humble: mammals, and we are mammals have this same age suppressing gene. So I started doing research. And we found out the Klotho, named after one of the Three Fates. In Greek mythology, the one who's fun, the thread of light of life, excuse me, is not only a gene, but it's a protein.

Hilary DeCesare: 00:07:52

So interesting. So

Hilary DeCesare: 00:07:54

Dr. Gail Humble: you cannot transfer

Hilary DeCesare: 00:07:57

It's a gene and a protein for it. And is there anything else in our bodies that act the same way as a gene and a protein? Or is it only isolated in this, this close up?

Hilary DeCesare: 00:08:09

Dr. Gail Humble: It's very unique, very unique. One of its kind.

Hilary DeCesare: 00:08:14

Okay, and it's great. And you said it was named after the Greek? Is it of one of the Three Fates,

Hilary DeCesare: 00:08:20

Dr. Gail Humble: the one who's slung the thread light? If she was, you're known for her beauty? And her intelligence?

Hilary DeCesare: 00:08:28

Oh, okay. Kind of sounds like you, I like this. Okay. And we've got, so we've got you, you now have identified this. And we know that if we don't have or it's downregulation. Does that mean it just it's not as prevalent? What is downregulation mean? Correct.

Hilary DeCesare: 00:08:47

Dr. Gail Humble: Genes are part of your DNA when they are turned on. And given a little kick, they'll over produce that is called an upregulation. In the case of the Klotho gene, when it over produces, it makes more Klotho protein, and we'll talk about how that works in a minute. Okay. When the gene is downregulated it makes less protein. So now what is happening in a way that you can understand because this does get science heavy, but I'm going to make it really simple.

Hilary DeCesare: 00:09:28

I mean it down. I just, I understand that I like act act like I'm a first grader that says I want you to be with me, okay, okay. So I following I am following so far.

Hilary DeCesare: 00:09:40

Dr. Gail Humble: One the Klotho protein gets into a cell it increases something called Super oxide dismutase. It's also called sod just like the grass. When this is increased, and this protects your cell from all oxidative stress. Now, that is one of the three reasons that we age. That is why the mouse slipped 31% longer. It all makes sense. It's 1/3 of the reason we ah, what

Hilary DeCesare: 00:10:15

are they very quickly? What are the other two reasons? Genetics, okay, genetics,

Hilary DeCesare: 00:10:22

Dr. Gail Humble: and then also Glice, nation inflammation, and that

Hilary DeCesare: 00:10:26

darn inflammation thing is coming up again.

Hilary DeCesare: 00:10:31

Dr. Gail Humble: So, on a cellular level, if you can block all today's stress completely, that cell is going to last, live longer. It's different than an antioxidant. You may be asking, Well, isn't that what Vitamin C is and everything. Antioxidants, allow the damage to happen, and then correct. When you get the cloth of protein involved, it doesn't allow any damage to happen. Clearly, it's the better way to go. So unfortunately, you can't really transfer genes you are what you are, you have certain genetic history. But what we decided to do, was taking adult mesenchymal stem cell in a lab from that. And using kind of a vector, think like a virus, we turned on the switch on the Klotho gene and the stem cell. So it's now over producing the Klotho protein. I want you all to visualize a petri dish, if you remember your high school biology. Yes, stem cells sit there, and you have to feed them because they're alive. And they kind of excrete a fluid. That fluid is called the sell condition media. I don't know if you've heard of skin, medica and Neocutis. They were the original two lines. Yeah, harvest the fluid or cell conditioned medium into their skincare products. So we went way beyond that. We genetically modified the stem cell to upregulate, the Klotho gene, and got the Klotho protein and second generation birth factors in the cell conditioned media.

Hilary DeCesare: 00:12:22

Okay, so wait, hold on. Because I have to say, when you say genetically modified, I think of all the bad things out there. But yet, what you're doing is actually great, because you're allowing for what you're ultimately going for, which is more of the more of this gene.

Hilary DeCesare: 00:12:45

Dr. Gail Humble: When there's so much more, it's not more of the gene. It's the results of the gene,

Hilary DeCesare: 00:12:50

and giving us the anti aging. And we're going to talk about the cellular

Hilary DeCesare: 00:12:54

Dr. Gail Humble: studies and the clinical studies in a minute. So you understand exactly what this does. But in many ways, this sheen prolongs life on a cellular level, and then of course, in the whole being Got

Hilary DeCesare: 00:13:08

it, okay.

Hilary DeCesare: 00:13:10

Dr. Gail Humble: So we were trying to get a cell line that would stabilize and live and reproduce. That produces a high level of wealth of protein. And we did this now this is one years of research. It's all self funded. This has been a passion project,

Hilary DeCesare: 00:13:30

now funded. That's what I just heard. Nia,

Hilary DeCesare: 00:13:34

Dr. Gail Humble: do many times too, we actually started another patent. And we was working, we were working in another with another component. And we thought we had it and I actually killed the cells after about five years of research. It's funny because I was sitting around with the scientists because we have two scientists that work with us one day, and a little Indian scientist said, you know, it's too bad people don't like GMO. And I said, Oh, honey, women may not want GMO in their tomatoes. But if you can genetically modify their skin without the risk. They're gonna be lining up around the clock, no doubt. So that's what set us on this other path.

Hilary DeCesare: 00:14:19

Right? What a great way to say that because you're right, we don't want we don't want the bad stuff in our body. But we definitely want if it is not if it's gonna be a healthy way to stay young and not have all of the you know, toxic horrible types of products that we you know, unless you're really careful, you're putting on your body every single day. We do this is what we want. So now help me understand. Okay, so you have been doing this for 20 years. You had this failed one. Wouldn't it? It would have been very easy for you, Dr. Gail to all of a sudden say, You know what? I am done. What kept you going?

Hilary DeCesare: 00:15:06

Dr. Gail Humble: Well, absolutely. I mean, you could have asked me anytime in the last two years if I could just sell my money back whether I would walk away and absolutely. But I knew we had something when we launched with this cloth of skin, and it's made of a made up of 25% of the cell condition medium we're talking about. We did clinical studies, and we found out there was a 30% reduction in photo damage in three months in our patients. Then we went further. And we had another very famous dermatologist in Beverly Hills to study at 20 patients. And she found 2.5 times global improvement in three months.

Hilary DeCesare: 00:15:59

I do have to ask you, Dr. Yael, because this is fascinating. Okay. We've heard so many times, that it's not what you put on your skin, it's what you put inside your body that will then come out in your skin. What you're talking about is a product line that you've created, but it is topical. How is it different than what we've heard that, you know, yeah, there's a whole bunch of stuff you can put on but it never, you know, it has to come from within, not from on top?

Hilary DeCesare: 00:16:32

Dr. Gail Humble: That's a great question, actually. So the Klotho protein is a large molecule. And we use liposomal technology to cloak it so that your skin thinks it's lipid or fat, it goes through your skin and it gets into your fiber loss cell, those are your skin cells, then it increases solid or superoxide dismutase. And your fibroblast cell begins to have resistant to oxidative stress. That's why you see results so fast to three months, and why they're so exceptional. A couple of the things are going on here, though, that are really important. We did a couple cellular studies that I want to discuss. One, we took five last and we had a control and the other ones we made in the Klotho self condition medium. And then we do do UV a radiation. Now that's the radiation that generally causes tumors in our skin.

Hilary DeCesare: 00:17:36

Is that just from is the UVA is that just sign just sun?

Hilary DeCesare: 00:17:40

Dr. Gail Humble: Just Sun

Hilary DeCesare: 00:17:41

okay. Yeah, you got to dummy down all of this because I might, I feel like I want to have everyone out there really understand this, because it's just been, it's been so eye opening, what I have had a chance to learn through you and I want them to be able to, but it does get a little bit over our head. So again, some damage coming in, you had one sample that had that and then you had the other one. And tell us what happened.

Hilary DeCesare: 00:18:10

Dr. Gail Humble: We found that there was a 40% decrease in DNA damage one of the states and and near the Klotho protein when it got into the cell. Till now this is amazing, because I don't know if you know, but even all the sunblocks that are out there, there's a spectrum we don't cover. We dumbed it down then to just eight hours of sunlight and have the same results 40% reduction in DNA damage. We then went on with the cellular studies and found out at the right concentration, which is clearly the concentration in the in the product line. We actually increased to other genes, H turret and cert six. Now I think you know what a telomere is, it's kind of the holy grail of aging of a cell. Telomeres are little X's and as they bump around, they get shorter and shorter and then your cell dies. H turret insert six are chilling, they're protective. And they form like almost a little cap that say you're chilling there stays longer for a longer period of time and your cell lives longer. Turns out the Klotho protein interacts with this and actually increases those two other genes. So you're not only getting the result of the Klotho protein in preventative against oxidative stress, you're actually increasing to other genes and preserving the life of your children.

Hilary DeCesare: 00:19:48

How long does it average sell last?

Hilary DeCesare: 00:19:54

Dr. Gail Humble: That's complicated question.

Hilary DeCesare: 00:19:56

Okay, so you're saying that it's lasting longer and you're I'm wondering like, is it? What is cell turnover? Like? How fast is that? Because so for years,

Hilary DeCesare: 00:20:08

Dr. Gail Humble: for your skin cell turnover, you're looking at 21 to 28 days, three to four weeks.

Hilary DeCesare: 00:20:14

Okay? So as you continue to use the Klotho product that these jeans that you've created, and you say it takes about 90 days, three months, before you really see like the full benefit, what are you really seeing, after 90 days, what would be that like? Wow factor.

Hilary DeCesare: 00:20:39

Dr. Gail Humble: So you, you actually start seeing results in three weeks, but three months, your results are becoming permanent. And what we found, in a whole our studies was a reversal of the photo damage. Now that means a reduction with righteous wrinkles, and improvement in the texture and improvement in the elasticity. And the surprising one was an improvement in just Chromia or pigment. We did not expect that. But in our most recent study, I think I told you that the 2.5 times global improvement, disk Chromia, or pigment was a big part of that.

Hilary DeCesare: 00:21:22

That's incredible. So here you are, you're finding all of these and how long has this product been out there?

Hilary DeCesare: 00:21:30

Dr. Gail Humble: You're we launched two years ago. And then we got Best Innovation in skincare within two weeks. And the path has been nonstop ever since. The interesting thing here is that I think we can even do more. We've only got three students right now we are going to add a min serum. But I think

Hilary DeCesare: 00:21:55

for those that don't know, you have three skews is three products. So you've got your eye serum, you've got your Skin Serum, and you have a night cream. That's

Hilary DeCesare: 00:22:10

Dr. Gail Humble: correct. Hmm, big one is the face serum that's 25% cell conditioned medium. That is something that you add to your skin first thing in the morning and first thing at night, just a very small amount, you don't have to change your regime, you don't have to do anything, that alone will give you the results. The eye serum again is a tiny amount morning and night. And the night cream is 10% of cell conditioned medium. And it kind of absorbs everything inside. And it's it's amazing. It's not greasy, it feels great. They smell great.

Hilary DeCesare: 00:22:47

I remember when I first got the products, I You had said, make sure to let them absorb before is it that you let them absorb, let's say the serum with nothing on your face. You put that on and then you let it absorb. For what five minutes until until you can put something else on it. Do you do the serum, five minutes and then you put the eye serum on for five minutes or can you put them on at the same time you

Hilary DeCesare: 00:23:19

Dr. Gail Humble: can put the eye and the face serum on for the same same time. But you want to let them absorb for it doesn't have to be a full five minutes. You don't want to dilute it. And then at night you add the night cream now I do have some before and after pictures that we can put up on the gallery.

Hilary DeCesare: 00:23:39

Let's totally do that. Because again, I've only been using this product for probably like five weeks. And the first I think week I wasn't I was putting you know, I was kind of doing the whole routine very quickly I was out there and then with this and that. And so I have in the last few weeks just started to really do what you had recommended, which is you know, always important to do everyone read the label. Okay, so now the results that you're finding how many people have actually gone through and used it and you have case studies around. So

Hilary DeCesare: 00:24:15

Dr. Gail Humble: the first study they got published and skin and ageing had 10 patients. The second study had 20 patients and it was done by an independent dermatologists. Her results were even more impressive than the ones I had in my office on my patients. We are now starting a third study. And that's going to be with another 20 patients this time we're going to have them use the face the I M tonight. In the prior studies we only added in the face serum. them why do we did nothing else. We didn't change their daily regime. If they didn't use sunblock, we didn't add sunblock. We let them be exactly the same and just by using this alone those are the results we found So what you did was

Hilary DeCesare: 00:25:01

did you take the before and after pictures, and then you really looked at it, what were you looking for?

Hilary DeCesare: 00:25:08

Dr. Gail Humble: We were looking for we used a dizzy of scan, I don't know if you know what that is, it is a objective scanner, using white lights. And we can show you all these pictures at the end. And they literally, it scans your face and shows your photo damage and ranks you one out of 100. And then we recheck the photos every month for three months, and re monitor it out of the 100 people. That's why we got the 30% improvement. And we're hoping to share this with you. And then we actually took before and after photos as well.

Hilary DeCesare: 00:25:47

That's incredible. That is so so now where do you go from here? You said you're going to add the men's product or the men's serum. But where were ultimately hope to take because we talked about this, that your non invasive, right? You're not for surgery, you're for really having your body do what it naturally should be able to do with enhancements like the Klotho gene. But what what's your what's your number one goal here?

Hilary DeCesare: 00:26:20

Dr. Gail Humble: Well, I think it's far beyond just the skincare line. I think that the Klotho gene, now that we understand what it does, it has many, many uses. Because every cell is affected. For example, UCSF is work University of San Francisco, is working with the Klotho gene, MIT Alzheimer's closin therapeutics, working with the Klotho gene and renal disease, close iGenex, which I just talked to the other day, they are trying to completely increase the Klotho gene in a being and they so far done that successfully with mice. They didn't tell me how they're doing this because it's a trade secret. The publication has not come out yet. But I think they're working with an mRNA virus. But if they can take a regular mouse and change it into a cloth over producing mouse, and the entire being is going to live 31% longer, and every system stay younger than once and for all we've actually changed the aging process. No one's ever been able to do that.

Hilary DeCesare: 00:27:37

And we first talked and you share that I was like this is this is where the future is going this sounds in my grandfather died of Alzheimer's and I have the APO or the a PO gene. That makes me more of a possible candidate for Alzheimer's. And so you go into a Mediterranean diet, there's all these things that you can do. And when I heard that, I'm like, wow, this is so incredible. The advancements that you're seeing now, not just with the face, right, which we definitely care about, but all these other areas. Dr. Gayle, it's incredible. I am like isn't exciting, John, it is such an exciting time. And so as I you know you are you're really cutting edge. There's when you first started from a field of you know, doctors and women versus man, you really were one of you. And are you seeing now that there are more females coming into this specific space that you're in?

Hilary DeCesare: 00:28:49

Dr. Gail Humble: Oh, absolutely. in all fields of medicine, my daughter, join vet school recently got accepted. And we went to the welcoming ceremony. 80% of the students were women. Oh, it wasn't a big change in the ratio the way it used to be. Had a ball.

Hilary DeCesare: 00:29:12

What do you attribute that to?

Hilary DeCesare: 00:29:15

Dr. Gail Humble: Clearly women are smarter and can vote. I think we're finally being given a chance. And we're unstoppable.

Hilary DeCesare: 00:29:29

Yeah, we really are. And you are too and thank you for all of the advancements that are going on. Where can people and it's so funny. Dr. Gale, I always say at the end of a show I say all right. So what's your favorite either beauty product or you know, what's the product or something that you would give to somebody that's your go to? Well, I have no doubt that this is your go to product. So So where can we where can we go to get this product? These products, we

Hilary DeCesare: 00:30:01

Dr. Gail Humble: sell it two ways we sell it from our website, which is Klotho with a k l o t h o skin.com. Or you can go to your dermatologist or plastic surgeon's office, they also are carrying it. And on the website, there's a list of offices there if you need access to them, but your

Hilary DeCesare: 00:30:23

website has, I know, that's actually where I picked up my recent stash of them. And I am you know what I'm gonna do, I'm gonna take a picture of my face, and just see, because I think that there, you know, a lot of times we forget, like, oh, yeah, I'm not really sure it works. And you're like, Well, wait a second, you want to go back and look at the picture from the before. So I'm excited about that. And then I'm going to ask last bit, if maybe Klotho is something that you're going to be saving up for? What can people do out there right now to start down a path? What do you or what are you when your patients come in your office? And you say, Hey, you should be doing these few things to really keep that youthful, the habits of youth going? What do you suggest?

Hilary DeCesare: 00:31:16

Dr. Gail Humble: Well, clearly, there have been studies that show if you diet regularly and keep a healthy diet and exercise regularly, you actually can increase your Klotho gene function in yourself. So that would be one thing I would say. Is

Hilary DeCesare: 00:31:34

there something in the diet that really, you know, we hear about eating more salmon because of the oils? What is it that what would you recommend food wise that could help us with the Klotho? Gene?

Hilary DeCesare: 00:31:48

Dr. Gail Humble: That's a very complicated question you asked me every

Hilary DeCesare: 00:31:51

question I'm asking. There's only been a couple of years. I know what

Hilary DeCesare: 00:31:54

Dr. Gail Humble: well, but the reality is the cloth a gene is tied in with the insulin pathway. So if you don't over eat, alright, I'll go back if this takes too much time, left me now. There was a study done many years ago, they had a group people that ate whatever they wanted. And another group that got the nutrition but was basically almost starved, although I'm not recommending that getting started. Which group do you think lived longer?

Hilary DeCesare: 00:32:25

Well, now that you started, probably the group that was getting starved. Exactly.

Hilary DeCesare: 00:32:28

Dr. Gail Humble: That's because of the insulin pathway and the Klotho interaction, this whole thing came full circle. So a lot of these diets now that you're seeing, and they're saying a launch or life, they don't even know why. But it's really involved in the cloth of Jean.

Hilary DeCesare: 00:32:47

So interesting. It's

Hilary DeCesare: 00:32:48

Dr. Gail Humble: fastening because every system ties in with another one. But as far as other recommendations, I would say, you don't even need to save your pennies. Like you said, I think we all have a drawer full of things we bought don't work

Hilary DeCesare: 00:33:06

to doubt. Yes. And that's really, when you and I were talking you're like you know all that stuff that claims don't have the studies behind it. Yours does the cloth,

Hilary DeCesare: 00:33:17

Dr. Gail Humble: and the technology and all the all the studies are right on the website, you can read them. So you can nerd out as much as you want to. And the before and afters are there as well as the Vizio scan. So I do urge everyone to go to the website and just read the technology and the studies we've done 20 years of research.

Hilary DeCesare: 00:33:36

I mean, it is it's fascinating where all of this is going and again, everyone we this is Dr. Gail, humble, we are so happy that you came today sharing this innovative new technology for wellness and aging. And now we understand a little bit more about the how does it all operate and why, as you said, throw out some of those junky products that claim they're doing things and start fresh. And I know another thing that you said is be very careful with like, you know, we we kind of, oh, we're using one product, we're using another I mean, Go in, go all in and really see how it can affect you. So we'll have all of this on this show notes section. And again, thank you, Dr. Gill for being here. Really appreciate it. We'll have you on again just to continue this journey.

Hilary DeCesare: 00:34:31

Dr. Gail Humble: Thank you very much.

Hilary DeCesare: 00:34:33

We'll talk to you soon.

Hilary DeCesare: 00:34:35

Dr. Gail Humble: Bye